A cellular and molecular view of T helper 17 cell plasticity in autoimmunity
نویسندگان
چکیده
منابع مشابه
CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity
1Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 2Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 3Department of Immunology and Microbial Disease, Albany Medical Center, Albany, NY, USA 4Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy 5Gastroen...
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The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh). These new subsets have many features in common, such as the ability to produce IL-21 and to express the IL-23 receptor (IL23R), the inducibl...
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In response to cytokine signalling and other factors, CD4-positive T lymphocytes differentiate into distinct populations that are characterized by the production of certain cytokines and are controlled by different master transcription factors. The spectrum of such populations, which was initially limited to Th1 and Th2 subsets, is currently broadened to include Th17 and Treg subsets, as well a...
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ژورنال
عنوان ژورنال: Journal of Autoimmunity
سال: 2018
ISSN: 0896-8411
DOI: 10.1016/j.jaut.2017.12.007